Other benzodiazepine drugs that can cause Suboxone interactions include Valium, Xanax, Halcion, and Klonopin. Given the risk of a severe Suboxone and Ativan interaction, these two medications generally should not be taken together. When taken together, Ativan and Suboxone can cause extreme sedation, as well as respiratory depression, coma, and death. Sometimes it is known by its generic name, lorazepam.Ĭonsequences of Mixing Ativan and Suboxone

When Suboxone is taken with gabapentin, interaction effects can lead to breathing problems, coma, and even death.Ītivan belongs to the benzodiazepine class of drugs, and it is used to treat anxiety. What Happens When You Mix Suboxone and Gabapentin?īoth Suboxone and gabapentin act as central nervous system depressants, meaning that they can interact with each other. Some people may take this medication to treat restless leg syndrome and diabetic nerve damage. Gabapentin is an anticonvulsant drug used to treat seizures. In some cases, mixing the two medications can increase sedation or cause respiratory depression. This enhances the side effects associated with the medication. What Happens When Suboxone Is Mixed With Erythromycin?Įrythromycin acts as a CYP3A4 inhibitor, and as such, it can increase levels of buprenorphine and enhance the opioid effects of Suboxone. This antibiotic medication acts as a CYP3A4 inhibitor, and it can increase levels of buprenorphine in the body. If you’re taking a medication on this list, it’s important to consult with your doctor to determine if it is safe to take the medication while on Suboxone. While it does cover the drugs that most commonly cause Suboxone interaction effects, it is not comprehensive.

The list below provides examples of what not to take with Suboxone. There are some general classes of drugs that should not be taken in combination with Suboxone, but it’s also helpful to know specific medications that can interact with it. What Medications Can You Not Take With Suboxone? It is always recommended to speak to your provider about possible drug interactions if you take more than one medication. The list above is not comprehensive, but it provides a general overview of what not to take with Suboxone. Serotonergic Drugs: These include medications called SSRIs, which are commonly used to treat depression. Also in this class of drugs are sleep medications and barbiturates.ĬYP3A4 Inhibitors and Inducers: CYP3A4 is an enzyme that plays an important role in drug metabolism, and certain drugs can affect the activity of this enzyme and make other medications less effective.Īntiretrovirals: This class of medications is used to manage HIV and is known to cause Suboxone interactions. Some people may take benzodiazepines to treat seizures.Ĭentral Nervous System Depressants: Benzodiazepine drugs are often classified as central nervous system (CNS) depressants, as they slow brain activity, like other CNS depressants. The Food and Drug Administration (FDA) warns of several classes of medications that can cause Suboxone interactions:īenzodiazepines: This class of drugs is used to treat anxiety, and they have a sedative effect.

The first part of understanding which medications cannot be taken with Suboxone is learning about what medications interact with this drug. There are many medications that can be safely taken with Suboxone, but others can cause interaction effects, which can range from mild to severe. If you have questions about Suboxone interactions with specific medications you are taking, it is important to consult with your Suboxone doctor. Some medications can be taken with Suboxone, whereas others cannot. Sometimes, interactions can be severe, so it is important to know the answer to, “What medications can you not take with Suboxone?Ĭan Suboxone Be Taken With Other Medications? While Suboxone is beneficial for those in opioid addiction treatment, there are some Suboxone drug interactions, meaning that certain medications may not be safe to take while on Suboxone. It contains two active medications: buprenorphine, which alleviates cravings and withdrawal by activating the same receptors that opioid drugs occupy, and naloxone, which causes withdrawal symptoms if a person misuses Suboxone. Suboxone is used in opioid addiction treatment to manage drug cravings and reduce withdrawal symptoms.

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